Catherine Heinzinger, DO
Catherine Heinzinger, DO
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Abstracts
Elucidating Circadian and Sleep Phenotypes and Relation to Cognitive Impairment in Alzheimer`s Dementia
In this comparative study of carefully AD biomarker-phenotyped and APOEƐ4-genotyped patients and normal cognition controls, less sleep time and more fragmented sleep are associated with poorer MMSE scores in MCI-AD. Preliminary results show cognitively normal participants at risk of AD(HR) do not show CRD seen in MCI-AD and are more consistent with controls (CL).
Heinzinger C
,
Wang L
,
Bena J
,
Bekris LM
,
Foldvary-Schaefer N
,
Pillai JA
,
Sujata Rao
,
Stephen Rao
,
Leverenz JB
,
Mehra R
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Evaluating the Impact of Sleep Disordered Breathing on Adverse Cardiovascular Outcomes After Bariatric Surgery
Preliminary data from this largest-to-date sample of systematically phenotyped patients with SDB undergoing bariatric surgery show significant differences in risk of MACE and MACE-free survival mitigated after consideration of obesity. Further investigation to elucidate effect modification by obesity and metabolic factors is needed.
Heinzinger C
,
Chindamporn P
,
Bena J
,
Wang L
,
Milinovich A
,
Kaw R
,
Kashyap S
,
Cetin D
,
Aminian A
,
Kempke N
,
Foldvary-Schaefer N
,
Aboussouan L
,
Mehra R
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Polysomnographic Measures of Sleep Architectural Disruption and Incident Atrial Fibrillation and Stroke in a Large Clinical Cohort
Objective measures of disrupted sleep architecture predicted incident AF in this clinical cohort. However, arousal index was not associated with AF development, nor stroke development in secondary analyses. Further investigation is needed to elucidate the role of arousal in SDB, perhaps with hierarchal models to clarify the degree to which confounders attenuate or accentuate any relationship.
Catherine M. Heinzinger
,
Nicolas Thompson
,
Alex Milinovich
,
Nancy Foldvary-Schaefer
,
David Van Wagoner
,
Mina Chung
,
Reena Mehra
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Sleep-Related Hypoxemia Association with Incident Atrial Fibrillation in a Clinic-Based Cohort
Sleep-related hypoxemia, defined by cumulative burden below 90% SaO2, demonstrated an association with incident AF in this large clinic-based cohort, even considering confounding factors. On the other hand, SDB severity as defined by AHI did not demonstrate this relationship. These findings are consistent with experimental models that identify intermittent hypoxia and oxidative stress leading to alterations of the cardiac substrate, thus implicating sleep-related hypoxemic mechanisms as a salient driver in the evolution of atrial arrhythmogenesis.
Catherine M. Heinzinger
,
Nicolas Thompson
,
Alex Milinovich
,
Nancy Foldvary-Schaefer
,
David Van Wagoner
,
Mina Chung
,
Reena Mehra
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